Fig. 4.

The immunopathogenic effects of IL-7 during experimental fungal asthma require both type 2 and IL-22 responses. a, b C57BL/6, Il1rl1−/− and Il22−/− mice were subjected to experimental fungal asthma and administered IL-7 as in Fig. 2. At 24 h after the last organism challenge, the right lungs were collected, homogenized and (a) CCL17 and (b) CCL22 levels were quantified in clarified lung homogenates by ELISA. The Figures illustrates cumulative data from four independent studies. For all graphs, *, ** and *** represent P values of <0.05, <0.01 and <0.001, respectively; n = 4–6 mice/group for each study; each data point/dot represents a single mouse and the line in each group corresponds to the mean