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. 2019 Jan 4;14(1):e0206394. doi: 10.1371/journal.pone.0206394

Fig 2. IVT topotecan slows leptomeningeal growth of D425 medulloblastoma cells in nude mice.

Fig 2

D425-ff-luc cells were inoculated into the cisterna magna of nude mice. The following day treatment with topotecan was started via the indicated route. Bioluminescence was evaluated until mice showed clinically apparent signs of tumor and were euthanized. (A) Bioluminescence imaging at day 14, which was the last imaging session when all mice in all groups were still alive. (B) Mean ± SEM of bioluminescence of each group. Means represent evaluations when all mice in the group were still alive, after which the curve is no longer shown. Below are p-values (log rank) comparing bioluminescence between the groups on day 14, which was the last imaging session when all mice were still alive. Saline IP, n = 8 mice; Saline IVT pump, n = 4; TPT IP, n = 9; TPT IVT pump, n = 6; TPT IVT bolus, n = 7.