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. 2019 Jan 4;14(1):e0210003. doi: 10.1371/journal.pone.0210003

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© 2019 Chen et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — A, Venn diagrams of miRNAs identified in SW480/ SW620 cell lysates (biological replicates combined) and for each cell line the number of unique miRNAs that selectively distribute to secreted EVs: sMVs and Exos. B, Correlation coefficient heat map shows limited variability between biological replicates (R1-2) and illustrates differences between miRNA profiles of SW480/SW620-CLs and their secreted EV subtypes. C, Differential miRNA expression analysis (log₂ FC >1 or <-1, p-value <0.05, FDR <0.05) in SW480/SW620 cell lines by edgeR revealed 134 dysregulated miRNAs (S2 Table). Of these, 73 are miRNAs down-regulated in SW620-CL and 61 up-regulated, relative to SW480-CL; the Venn diagrams show the number of dysregulated miRNAs that selectively distribute to SW480/SW620 secreted EVs.