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. 2019 Jan 4;14(1):e0210022. doi: 10.1371/journal.pone.0210022

Table 1. Clinical and operative characteristics of four surgical groups.

Clinical Characteristic I(N = 72) II(N = 23) III(N = 45) IV(N = 16) P
Age (years) 57.9±12.6 61.2±11.8 57.2±12.8 58.8±12.4 0.643
Gender(M/F) 50/22 15/8 31/14 10/6 0.942
Hypertension 60(83.3%) 20(87.0%) 32(71.1%) 11(68.8%) 0.229
Smoking 20(27.8%) 6(26.1%) 17(37.8%) 4(25.0%) 0.611
Coronary artery disease 11(15.3%) 0(0) 7(15.6%) 2(12.5%) 0.073
Hyperlipidemia 3(4.2%) 1(4.3%) 3(6.7%) 1(6.3%) 0.937
Chronic obstructive pulmonary disease 5(6.9%) 3(13.0%) 1(2.2%) 1(6.3%) 0.378
Diabetes mellitus 8(11.1%) 3(13.0%) 6(13.3%) 1(6.3%) 0.870
Cerebrovascular accident 6(8.3%) 4(17.4%) 7(15.6%) 0(0) 0.112
Previous cardiac surgery 0(0) 0(0) 1(2.2%) 0(0) 0.475
Previous aortic surgery 2(2.8%) 0(0) 2(4.4%) 0(0) 0.464
Chronic kidney disease 2(2.8%) 1(4.3%) 4(8.9%) 0(0) 0.304
Hemodialysis 0(0) 0(0) 2(4.4%) 0(0) 0.169
Marfan syndrome 4(5.6%) 0(0) 2(4.4%) 0(0) 0.308
Malperfusion 27(37.5%) 12(52.2%) 22(48.9%) 3(18.8%) 0.112
IA dissection 25 (34.7%) 10 (43.5%) 24 (53.3%) 5 (31.3%) 0.196
LCCA dissection 22 (30.6%) 14 (60.9%) 15 (33.3%) 6 (37.5%) 0.066
LSA dissection 20 (27.8%) 12 (52.2%) 13 (28.9%) 6 (37.5%) 0.156
Operative Characteristic
Brain protection (antegrade/retrograde) 49/23 22/1* 45/0* 16/0* <0.001
Cardiopulmonary bypass(min) 244.3±52.3 336.0±91.1* 317.6±92.8* 273.5±58.7# <0.001
Aortic clamp(min) 124.8±32.7 201.8±52.4*# 166.9±49.3* 147.5±46.0 <0.001
Circulatory arrest(min) 36.0±12.5 71.4±22.9*# 53.9±31.4* 53.6±29.0* <0.001
Primary tear location 0.195
    Ascending aorta 41 (56.9%) 15 (65.2%) 25 (55.6%) 9 (56.3%)
    Arch (lesser curvature) 9 (12.5%) 2 (8.7%) 5 (11.1%) 2 (12.5%)
    Arch (great curvature) 4 (5.6%) 4 (17.4%) 9 (20.0%) 3 (18.8%)
    Proximal descending aorta 6 (8.3%) 1 (4.3%) 4 (8.9%) 2 (12.5%)
    unknown 12 (16.7%) 1 (4.3%) 2 (4.4%) 0 (0)
Primary tear resection 48 (66.7%) 22 (95.7%)* 37 (82.2%) 11 (68.8%) 0.022
Root reconstruction 15(20.8%) 7(30.4%)# 3(6.7%)* 3(18.8%) 0.061
CABG 1(1.3%) 1(4.3%) 0(0) 0(0) 0.451
ASA classification (III/IV/V) 3/60/9 1/20/2 1/36/8 1/14/1 0.867

ASA: American Society of Anesthesiologists; CABG, Coronary artery bypass graft; IA, innominate artery; LCCA, left common carotid artery; LSA, left subclavian artery; Age, body temperature, cardiopulmonary bypass, aortic clamp, circulatory arrest by T test (normal distribution analysis by Kolmogorov-Smirnov test and Post Hoc test) and other variables by Chi-square test.

* p <0.05 vs. Group I

# p <0.05 vs. Group III.