Figure 2.

Regulation of the actin cytoskeleton in osteoclast resorption and migration states. In the stationary state, OCs are apical‐basally polarized with sealing zone (SZ) that contains actin and integrins, and area of membrane tightly juxtaposed to the bone surface that defines the resorption lacuna. SZ delineates the ruffled border where bone degradation takes places. Once the resorption stops, OCs enter into the migration state where they disassemble the SZ, flatten, and start the migration by becoming polarized with a leading and a trailing edge. Rac and Rho contribute to different states of OC biology. N, nuclei.