Table 1.
The Dataset of sdAbs Used in this Work
| PDB ID | Resolution (Å) | T m (°C) | CDR1 range | CDR2 range | CDR3 range |
|---|---|---|---|---|---|
| 4idl7 | 2.09 | 46.75 | Leu23–Gly35 | Ser50–Asp58 | Asn96–Ser112 |
| 1fvc9 | 2.20 | 58.00 | Ala23–His35 | Arg50–Arg59 | Ser97–Tyr109 |
| 4w708 | 2.28 | 60.00 | Thr23–Gly35 | Ala50–Phe62 | Ala100–Tyr118 |
| 1mel10 | 2.50 | 69.00 | Ala23–Gly35 | Ala50–Tyr59 | Ala97–Ser122 |
| 5sv411 | 2.70 | 70.70 | Thr23–Ala35 | Val50–Asp59 | Ala97–His115 |
| 3b9v12 | 1.80 | 79.00 | Ala23–Gly35 | Ser50–Arg59 | Ala97–Tyr109 |
| 4tyu8 | 2.13 | 85.00 | Thr23–Gly35 | Ala50–Phe62 | Ala100–Tyr118 |
Note: List of protein structures used in this work obtained from Protein Data Bank Japan with their respective resolution, T m value and the CDR loop ranges standardized to the numbering used in this work. The original sequence numbering of 3b9v in CDR2 and CDR3 correspond to Ser50–Ile51–Tyr52–Pro52A–Thr53–Asn54–Gly55–Tyr56–Thr57–Arg58 and Ala93–Arg94–Trp95–Gly96–Gly97–Asp98–Gly99–Phe100–Tyr100A–Ala100B–Met100C–Asp101–Tyr102, respectively.