Table 1.

An example wish-list for automated plan generation with Erasmus-iCycle for localised prostate cancer patients

Constraints
	Volume	Type	Limit
	PTV	Max dose	105% of DPx
	PTV	Mean dose	101% of DPx
	Rectum & anus	Max dose	102% of DPx
	PTV shell 50mm	Max dose	50% of DPx
	Unspecified tissues	Max dose	105% of DPx
Objectives
Priority	Volume	Type	Goal	Parameters
1	PTV	↓LTCP	0.8	DPx = 78Gy, α = 0.8
2	Rectum	↓EUD	20Gy	k = 12
3	OAR 2	↓EUD	10Gy	k = 8
4	PTV shell 5mm Skin ring 20mm	↓Max dose ↓Max dose	80% of DPx 20% of DPx
5	Rectum	↓Mean dose	5Gy
6	Anus	↓Mean dose	5Gy
7	Bladder	↓Max dose	5Gy
8	PTV shell 15mm PTV shell 25mm	↓Max dose	50% of DPx 30% of DPx
9	Left & right femoral heads	↓Max dose	50% of DPx

α, cell sensitivity;EUD, equivalent uniform dose;k, volume effect; LTCP, logarithmic tumour control probability; PTV, planning target volume;D_Px, prescribed dose.

The priorities assigned to the objectives are used in the a priori MCO, guaranteeing for each patient generation of a pareto-optimal plan with clinically favorable balances between all treatment objectives. (Courtesy: A.W. Sharfo).