. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: J Drug Target. 2018 Jan 9;26(5-6):420–434. doi: 10.1080/1061186X.2017.1419362

Table 1:

Pre-clinical applications of ultrasound molecular imaging

Application	Disease	Animal	Molecular target	Reference
Angiogenesis	Breast tumor	Mouse	α_vβ₃	[128]
		Mouse	VEGFR2	[87,89]
		Mouse	VEGFR2, α_vβ₃, P-selectin	[54]
		Rat	VEGFR2	[40]
	Pancreatic tumor	Mouse	VEGFR2	[90]
		Mouse	VEGFR2, VEGF, CD105	[123]
		Mouse	Thy1/CD90	[121]
		Rat	VEGFR2	[134,135]
	Glioma tumor	Rat	α_vβ₃	[136]
	Ovarian tumor	Hen	α_vβ₃	[157]
	Other tumor	Mouse	α_vβ₃	[158,159]
		Mouse	VEGFR2	[88,105,129–133]
		Mouse	VEGFR2, α_vβ₃	[124]
		Mouse	VEGFR2, α_vβ₃, endoglin	[125,126]
		Mouse	VEGFR2, α_vβ₃, P-selectin	[127]
		Mouse	alpha(v)-integrins	[160]
		Mouse	B7-H3/CD276	[122]
		Mouse	PSMA	[119]
		Mouse	SFRP2	[120]

Inflammation	Atherosclerosis	Mouse	VCAM-1	[94,138]
		Mouse	VCAM-1, P-selectin	[95]
		Swine	VCAM-1, ICAM-1	[139]
		Primate	VCAM-1, P-selectin	[140]
	Renal ischemia	Mouse	Leukocyte	[154]
	Myocardial ischemia	Mouse	P-selectin	[92,93]
		Mouse	P-selectin, E-selectin	[141]
		Rat	E-selectin	[142]
		Rat	P-selectin, E-selectin	[143]
		Primate	P-selectin, E-selectin	[144]
	Transplant rejection	Rat	ICAM-1	[91]
	Bowel disease	Mouse	P-selectin	[145]
		Mouse	MAdCAM-1	[45]
		Mouse	P-selectin, E-selectin	[146]
		Swine	P-selectin, E-selectin	[147]

Thrombosis	Acute thrombosis	Mouse	Glycoprotein IIb/IIIa	[151,161]
		Rat	Glycoprotein IIb/IIIa	[150]