Table 4.
Untreated High-Grade Tumors: Factors Associated With Establishment
| High-Grade Untreated Tumors (n = 42) | High-Grade Untreated Establishment-Rate (n = 26) | Xenograft Establishment | ||||
|---|---|---|---|---|---|---|
| No. | % | No. | % | OR | P | |
| Sex | ||||||
| Female | 21 | 50.0 | 12 | 57.1 | 0.667 | 0.526 |
| Male | 21 | 50.0 | 14 | 66.7 | ||
| Presentation | ||||||
| Primary | 27 | 64.3 | 18 | 66.7 | ||
| Recurrent or metastatic | 15 | 35.7 | 8 | 53.3 | ||
| Location | ||||||
| Abdomen/retroperitoneum | 22 | 52.4 | 12 | 54.5 | ||
| Extremity | 20 | 47.6 | 14 | 70.0 | 1.944 | 0.306 |
| Size, cm | ||||||
| < 10 | 30 | 71.4 | 17 | 56.7 | ||
| > 10 | 12 | 28.6 | 9 | 75.0 | 2.294 | 0.276 |
| Subtype | ||||||
| Leiomyosarcoma | 12 | 28.6 | 7 | 58.3 | ||
| Liposarcoma | 9 | 21.4 | 7 | 77.8 | ||
| NOS/spindle cell/UPS | 7 | 16.7 | 6 | 85.7 | ||
| Other | 14 | 33.3 | 6 | 42.9 | ||
| Xenograftability | ||||||
| Success | 26 | 61.9 | 26 | 100.0 | ||
| Failure | 16 | 38.1 | 0 | 0.0 | ||
| Median age, years (range) | 63 (16–91) | 66 (16–91) | 1.020 | 0.290 | ||
| Median size, cm (range) | 6.9 (0.9–23.8) | 8.25 (1.5–23.8) | 1.143 | 0.084 | ||
| Median time to establish, days (range) | 61.5 (9–184) | 61.5 (9–184) | ||||
Abbreviations: NOS, not otherwise specified; OR, odds ratio; UPS, undifferentiated pleomorphic sarcoma.