Table 1.
Overview of preclinical experiments and results for Rho kinase inhibitors.
| ROCK inhibitors | Results |
|---|---|
| Y-27632 | ↓ IOP |
| ↑ Conventional outflow | |
| ↑ Pupil dilation | |
| ↓ Contraction of CM and TM cells | |
| ↑ Changes in TM and SC cell morphology | |
| ↑ SC cell monolayer permeability | |
| ↓ MLC phosphorylation in TM and SC cells | |
| ↑ Separation between inner wall and juxtacanalicular connective tissue corresponding to increased outflow | |
| ↓ Scar after surgery | |
| ↓ Scar in cell model | |
| HA-1077 AT877 Fasudil |
↓ IOP |
| ↑ Conventional outflow | |
| ↓ Actin bundles and focal adhesions in TM cells | |
| ↓ CM contraction | |
| ↓ Scar in cell model | |
| H-1152P | ↓ IOP |
| ↑ Conventional outflow | |
| ↑ Cell separation in TM cells | |
| ↓ Actin bundles and focal adhesions in TM cells | |
| ↓ MLC phosphorylation in TM cells | |
| ↓ Scar in cell model | |
| 2,3-diaminopyrazine | ↓ IOP |
| RKI983 SNJ-1656 Y-39983 |
↓ IOP |
| ↑ Conventional outflow | |
| ↓ TM contraction | |
| Benzothiophenes | ↓ IOP |
CM: Ciliary muscle; IOP: Intraocular pressure; MLC: Myosin light chain; ROCK: Rho kinase; SC: Schlemm’s canal; TM: Trabecular meshwork.