Table 1.
Demographics and clinicopathological characteristics
| Parameters | FMUUH (n=4,262) | MSKCC (n=1,378) | p |
|---|---|---|---|
| Age | 60 ± 11 | 64 ± 13 | <0.001 |
| Male gender | 3201 (75.1) | 881 (63.9) | <0.001 |
| BMI | 22.2 ± 2.9 | 27.7 ± 5.2 | <0.001 |
| Ethnicity | <0.001 | ||
| White | 0 (0) | 1096 (79.5) | |
| Black | 0 (0) | 87 (6.3) | |
| Asian | 4262 (100.0) | 155 (11.2) | |
| Others | 0 (0) | 40 (2.9) | |
| Comorbidities present | 1139 (26.7) | 562 (40.8) | <0.001 |
| Tumor locationa | <0.001 | ||
| Proximal | 1156 (27.1) | 685 (49.7) | |
| Middle | 804 (18.9) | 250 (18.1) | |
| Lower | 1737 (40.8) | 410 (29.8) | |
| Mixed | 565 (13.3) | 33 (2.4) | |
| Undifferentiated histologyb | 3089 (72.5) | 830 (60.2) | <0.001 |
| Tumor size (cm) | 5.1 ± 2.8 | 3.4 ± 2.8 | <0.001 |
| Depth of invasionc | <0.001 | ||
| T1 | 807 (18.9) | 539 (39.1) | |
| T2 | 452 (10.6) | 196 (14.2) | |
| T3 | 920 (21.6) | 408 (29.6) | |
| T4a | 1630 (38.2) | 227 (16.5) | |
| T4b | 453 (10.5) | 8 (0.6) | |
| No. of metastatic lymph nodesd | <0.001 | ||
| 0 | 1327 (31.1) | 771 (56.0) | |
| 1-2 | 580 (13.6) | 261 (18.9) | |
| 3-6 | 738 (17.3) | 183 (13.3) | |
| 7-15 | 939 (22.0) | 150 (10.9) | |
| ≥16 | 678 (15.9) | 13 (0.9) | |
| TNM stagee | |||
| I | 984 (23.1) | 617 (44.8) | <0.001 |
| II | 799 (18.7) | 417 (30.3) | |
| III | 2479 (58.2) | 344 (25.0) | |
| D2 lymphadenectomyf | 4133 (97.0) | 1333 (96.7) | 0.656 |
| No. of lymph nodes retrieved | 32 ± 12 | 26 ± 11 | <0.001 |
| No. of positive lymph nodes | 7 ± 9 | 2 ± 4 | <0.001 |
| No. of negative lymph nodes | 25 ± 13 | 24 ± 10 | 0.001 |
| Type of gastrectomy | <0.001 | ||
| Total | 2365 (55.5) | 342 (24.8) | |
| Distal | 1827 (42.9) | 527 (38.2) | |
| Proximal | 70 (1.6) | 509 (36.9) | |
| Received pre-op chemotherapy | 91 (2.1) | 645 (46.8) | <0.001 |
| Received post-op chemotherapy | 1618 (38.0) | 299 (21.7) | <0.001 |
Adenocarcinoma of the esophagogastric junction within the stomach was categorized as proximal third gastric cancer;
Histology subtype was categorized as differentiated (well-differentiated and moderately differentiated adenocarcinoma) or undifferentiated (poorly differentiated adenocarcinoma and signet ring cell carcinoma);
Depth of invasion includes p-depth of invasion and yp-depth of invasion;
No. of metastatic LNs includes p- No. of metastatic LNs and yp- No. of metastatic LNs;
TNM stage includes p-TNM stage and yp-TNM stage. p refers to the postoperative pathology for patients receiving surgery without preoperative chemotherapy. yp refers to the postoperative pathology for patients receiving surgery with preoperative chemotherapy.
All other patients underwent D1 lymphadenectomy.