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. Author manuscript; available in PMC: 2019 Aug 3.
Published in final edited form as: Sci Immunol. 2018 Aug 3;3(26):eaao4747. doi: 10.1126/sciimmunol.aao4747

Figure 8: Lung NETosis in severe asthma correlates with BALF IL-17.

Figure 8:

(A) Picogreen assays of BALF DNA in biospecimens from healthy donors (HD) and subjects with non-severe asthma (NSA) and severe asthma (SA). (B) BALF DNA levels were further stratified into low neutrophil (PMN) (< 5 %) and high PMN (> 5 %). (C) Representative western blot showing hyper-citrullinated histone H3 in BALFs from HD, NSA and SA with low or high PMN count (top panel) and Ponceau S stain as loading control (bottom panel). (D) Correlation between BALF DNA and PMN count in SA. (E) Correlation between BALF IL-17 levels and number of PMN (F) Correlation between BALF IL-17 levels and number of BALF cytoplasts. Pearson correlation r values and significance are noted for each correlation and regression lines are shown.