Table 1:
IC50 values
IC50 values (μmol/L ± SEM) | ||||
---|---|---|---|---|
F10 | F10 resistance factor | 5-FU | 5-FU resistance factor | |
HCT116 p53+/+ | 0.059 ± 0.010 | 0.00 | 8.072 ± 0.968 | 0.00 |
HCT116 p53−/− | 0.098 ± 0.034 | 1.66 | **29.785 ±3.919 | 3.75 |
HCT116 P53R248W/+ | 0.100 ± 0.033 | 1.69 | **20.893 ± 2.469 | 2.63 |
HCT116 p53R248W/− | 0.497 ± 0.206 | 8.42 | **69.502 ± 12.792 | 8.63 |
IC50 values (μmol/L) after 72 h drug treatment of each indicated drug. Experiment done in triplicate ± SEM. Resistance factor indicates the fold increase in IC50 values for the indicated drug compared to the wild-type HCT116 cell line. Data analyzed using Graphpad Prism (n = 4;
P ≤ 0.01)