Table 1.

Summary of the Analysis Targeting Candidate Genes

	DEX			DEX × Sex		Data From the Literature
Gene	No. of Important Probes	Probe Location	Direction of Change in Methylation	No. of Important Probes	Probe Location	Tissue	Cohort	Reference
BDNF	2	TSS1500; TSS200; 5′UTR; body	Hypermethylation	2	TSS1500; TSS200; 5′UTR; body; first exon	Peripheral blood cells	Major depression	[24]
HSD211B2	1	Body	Hypermethylation	1	Body	Placenta	Newborns	[28]
NR3C1	2	TSS1500; 5′UTR	Hypermethylation	1	5′UTR	Cord blood and maternal blood	Maternal depression	[26]
NR3C2	1	5′UTR	Hypermethylation	1	5′UTR	N.A.	N.A.	–
FKBP5	3	TSS1500; 5′UTR	Hypermethylation	3	TSS1500; 5′UTR	Peripheral blood cells	Childhood trauma	[25]
LTA	3	TSS1500; body	Hypermethylation	6	TSS1500; TSS200; 5′UTR; first exon	CD3+ T cells	PNMS exposure	[12]
TNF	9	TSS1500; first exon; body; 3′UTR	Hypermethylation	4	TSS1500; first exon; 3′UTR	N.A.	N.A.	–
SCG5	2	5′UTR	Hypermethylation	2	5′UTR	CD3+ T cells	PNMS exposure	[12]
SLC6A4	1	Body	Hypermethylation	1	Body	T Cells and monocytes	Childhood aggression	[27]

For each gene, the number of important probes, their location, and the direction of change in methylation are presented. Probes were analyzed in a linear model, including age and sex as covariates. Significance was defined as an uncorrected P < 0.05. NR3C2 and TNF were not identified in the literature but were included as candidate genes as a result of their biological roles relative to the candidate genes NR3C1 and LTA.