Table 2.

Summary of the Analysis Targeting Candidate Genes Involved With the Regulation of DNA Methylation

Gene	Probe ID	Location	P[DEX]	β[DEX]	P[DEX × Sex]	β[DEX × Sex]
DNMT1	cg21892967	TSS1500	0.007	-0.02	0.511	0.01
DNMT1	cg01347596	Body	0.038	0.01	0.005	-0.02
DNMT1	cg15043801	TSS200	0.147	−0.01	0.034	0.01
DNMT1	cg07058526	Body	0.232	0.01	0.036	-0.02
DNMT3A	cg23042148	Body	0.005	0.04	0.034	-0.04
DNMT3A	cg10239163	Body	0.000	0.07	0.010	-0.07
DNMT3A	cg23903708	Body	0.002	0.04	0.003	-0.06
DNMT3A	cg00050692	Body	0.002	-0.06	0.054	0.05
DNMT3A	cg15150970	Body	0.005	0.03	0.025	-0.03
DNMT3A	cg15843262	Body	0.061	0.03	0.025	-0.04
DNMT3A	cg17137500	5′UTR	0.061	0.01	0.014	-0.02
DNMT3A	cg19256292	5′UTR	0.088	0.01	0.037	-0.02
DNMT3A	cg26544247	Body	0.098	0.02	0.027	-0.04
DNMT3A	cg23393100	Body	0.145	0.00	0.023	-0.01
DNMT3A	cg10270719	5′UTR	0.197	0.00	0.022	-0.01
DNMT3B	cg13636640	TSS1500	0.014	0.04	0.057	−0.05
DNMT3B	cg22052056	5′UTR	0.067	0.02	0.147	−0.02
DNMT3B	cg09835408	5′UTR	0.092	0.03	0.028	-0.05
DNMT3L	cg26398867	Body	0.016	0.01	0.057	−0.01
TET1	cg02774862	5′UTR	0.029	0.03	0.041	-0.03
TET1	cg14506140	Body	0.073	0.00	0.023	0.01
TET1	cg15254238	5′UTR	0.106	0.02	0.027	-0.05
TET2	cg12306086	5′UTR	0.007	0.05	0.010	-0.07
TET2	cg20586654	5′UTR	0.500	0.00	0.030	-0.01
TET2	cg11508949	TSS200	0.887	0.00	0.023	-0.01
TET2	cg09295382	5′UTR; first exon	0.332	0.00	0.008	0.01
TET3	cg13808088	3′UTR	0.140	0.01	0.013	-0.01
KDM1A	cg26662347	TSS200	0.035	0.00	0.044	-0.01
KDM1B	cg00102920	TSS1500; 5′UTR	0.044	0.00	0.170	0.00
KDM1B	cg07465480	TSS1500; 5′UTR	0.258	0.00	0.021	0.01

The probe locations and the direction of change in methylation are shown for probes importantly associated with the prenatal DEX treatment or with the DEX × sex interaction. Probes were analyzed in a linear model, including age and sex as covariates. Significance was defined as an uncorrected P < 0.05. Significant results are marked in boldface.

Abbreviation: ID, identification.