Table 1.
Deconvolution Analysis of the LH and T Profiles During 7.5 H of Continuous and Pulsatile T Infusions
| Continuous T | Pulsatile T | P Value | |
|---|---|---|---|
| LH | |||
| Pulse frequency, no./7.5 h | 3.6 ± 0.34 | 3.3 ± 0.23 | 0.32 |
| Fast half- life, min | 6.93 | 6.93 | 1.0 |
| Long half- life, min | 57 ± 4.4 | 62 ± 4.3 | 0.38 |
| Mode, min | 13 ± 0.7 | 13 ± 0.9 | 0.94 |
| Basal secretion, IU/L/7.5 h | 29.2 ± 3.9 | 28.9 ± 5.6 | 0.95 |
| Pulsatile secretion, IU/L/7.5 h | 25.6 ± 2.3 | 23.3 ± 2.4 | 0.39 |
| Total secretion, U/L/7.5 h | 54.8 ± 5.8 | 52.2 ± 7.1 | 0.62 |
| Mean pulse mass, U/L | 7.7 ± 0.8 | 7.4 ± 0.8 | 0.76 |
| T | |||
| Pulse frequency, no./7.5 h | 5.4 ± 0.4 | 6.2 ± 0.4 | 0.26 |
| Fast half- life, min | 1.4 | 1.4 | 1.0 |
| Long half- life, min | 18.5 ± 1.1 | 15.0 ± 0.4 | 0.016 |
| Mode, min | 11.9 ± 1.5 | 13.1 ± 1.6 | 0.64 |
| Basal secretion, IU/L/7.5 h | 7070 ± 500 | 9050 ± 550 | 0.002 |
| Pulsatile secretion, IU/L/7.5 h | 530 ± 54 | 1020 ± 160 | 0.008 |
| Total secretion, U/L/7.5 h | 7600 ± 520 | 10,070 ± 630 | 0.001 |
| Mean pulse mass, U/L | 99 ± 8.2 | 162 ± 18.5 | 0.003 |
Data are shown as means ± SEM. Statistical comparison between the two groups was done with the two-tailed Student t test for paired data. P < 0.01 was considered significant.