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A CRISPR-Cas9 transcriptional reporter of KAT activity. (a) Scheme for induction of acetylation/gene expression by dCas9-p300, first reported by Gersbach et al. (b) Domain architecture of dCas9-p300 fusion. (c) Activation of model inducible genes IL1RN, RHOXF2, and TTN by dCas9-p300 in HEK-293 cells. D1399Y refers to a dCas9-p300 construct harboring a mutation to the KAT catalytic domain.
