Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
KAT-dependent gene expression can be stimulated using diverse genomic recruitment strategies. (a) Crystal structure of Cas9-sgRNA complex (PDB 4OO8) illustrating sites for short guide RNA engineering. (b) Cartoon schematic of dCas9-dependent recruitment of MS2-p300 fusions using sgRNA 2.0. (c) Comparison of KAT-dependent expression of IL1RN using dCas9-p300 and MS2-p300 with sgRNA 2.0 architectures.
