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. Author manuscript; available in PMC: 2019 Feb 16.
Published in final edited form as: ACS Chem Biol. 2018 Jan 17;13(2):455–460. doi: 10.1021/acschembio.7b00883

Figure 3.

Figure 3.

Influence of small molecule stimuli on CRISPR-Cas9 acetyltransferase. (a) Single point screening data. Single point concentrations are provided in the Supporting Information. Patent KATi = NCGC00496795. (b) Structures of bromodomain-targeting small molecules identified as inhibitors of dCas9-p300-dependent gene expression. (c) Dose-dependent inhibition of KAT-dependent gene expression by NCGC00496795. (d) Dose-dependent inhibition of KAT-dependent gene expression by JQ1. (e) JQ1 alters dCas9-p300-dependent gene expression but not SAM-dependent gene expression.