FIGURE 2:

Schematic representation of the PET imaging hypothesis connecting the protein cascade from oncogenic MYC expression to surface transferrin receptor expression (TfR) in pancreatic cancer. High MYC activity, especially in the context of oncogenesis, will directly result in amplified expression of TfR, subsequently formulating an imaging target for radiolabeled transferrin. This correlation is represented across multiple cohorts as [⁸⁹Zr]Zr-Transferrin has increased uptake in tumors with higher protein expression of both MYC and TfR, and is observed in preclinical models of controlled KRAS dependency and via target engagement along the KRAS oncogenic cascade.