Figure 6: Full tendon detachment and repair results in functional changes and recruitment of Axin^lin scar cells.

(A) Paw area is generally significantly increased in both limbs of injured animals compared to limbs of non-injured animals. (B, C) Toluidine blue staining of supraspinatus tendon sections show disruption of enthesis organization and characteristic orientation with massive scar formation. Lineage tracing using (D) Sox9^CreERT2 shows TdTomato+ cells in enthesis fibrocartilage with no labeling in the scar. (E) Axin2^CreERT2 tracing shows little labeling of enthesis fibrocartilage but considerable presence of TdTomato+ cells in the scar. Yellow dashed outlines enclose similar regions. Green dashed line indicates detachment site. Black scalebars: 200μm. White scalebars: 100μm.