Fig. 4.

Amyloid β binds directly to Candida albicans in vivo. a Wild-type mice were challenged with C. albicans as in Fig. 2, and immunofluorescence staining for DAPI, IBA1, Aβ, and GFAP was performed on brain sections containing fungal granulomas. b Repeat staining of fungal granulomas for DAPI, IBA1, Aβ, and calcofluor white (CW) comparing wild-type to app^−/− mice. c, d Aβ 1–42 and 1–40 levels from whole-brain homogenates as assessed by ELISA. (n = 4, mean ± S.E.M, *p < 0.05, and **p < 0.01 using one-way ANOVA followed by Dunnett’s test for multiple comparison. Scale bar: 20 μm). Data are shown as representative of three independent experiments