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. 2018 Dec 17;116(1):52–57. doi: 10.1073/pnas.1808950116

Fig. 5.

Fig. 5.

In situ visualization of crucial metabolites and metabolic enzyme in the uridine metabolism pathway (A) and histidine metabolism pathway (B). (A1 and A2) MS images of uridine and uracil. (A3 and A4) Uridine and uracil levels in cancer and paired epithelium and muscle tissues from 256 ESCC patients (means ± SD). ***P < 0.001. (A5) UPase1-mediated metabolic process of converting uridine to uracil. (A6) The newly constructed MS image based on the ion-intensity ratio of uracil to uridine. (A7) Scanning path of AFADESI-MSI. (A8) Plot of the intensity changes of uridine and uracil occurring during the transition from cancer, muscle, to epithelial tissue. (A9) Expression of UPase1 in different regions of an ESCC tissue section. (B1 and B2) MS images of histidine and histamine. (B3 and B4) Histidine and histamine levels in cancer and paired epithelium and muscle tissues from 256 ESCC patients. (B5) The HDC-mediated metabolic process of converting histidine to histamine. (B6) The newly constructed MS image based on the ion-intensity ratio of histamine to histidine. (B7) Plot of the intensity changes of histidine and histamine occurring during the transition from cancer, muscle, to epithelial tissue. (B8) Expression of HDC in different regions of an ESCC tissue section. CT, cancer tissue; ET, epithelial tissue; MT, muscular tissue.