Fig. 1.

hMGE-like cell grafting into the hippocampus after SE greatly restrained the frequency and intensity of SRS in the chronic phase. Data from 3 wk of continuous EEG recordings measured in the fifth month after SE are illustrated for the SE-alone and SE + grafts groups (n = 6 per group). The frequency of all SRS (A1), the frequency of stage V SRS (A2), the duration of individual SRS (A3), and the percentage of time spent in SRS activity (A4) are compared. ****P < 0.0001. Additional analyses of SRS activity on a week-by-week basis demonstrated consistent reductions in all SRS (B1), stage V SRS (B2), and the percentage of time spent in SRS activity (B4) over 3 wk. As shown in A3 and B3, the duration of individual seizures was not different between the two groups in either analysis. ****P < 0.0001; NS, not significant.