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. 2018 Dec 17;116(1):287–296. doi: 10.1073/pnas.1814185115

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Copyright © 2019 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Cells derived from hMGE-like cell grafts placed into the hippocampus after SE pervasively migrated to different subfields and layers of the hippocampus. (A1) Example of migration of cells from an hMGE graft core located at the end of the hippocampal fissure. Magnified views of regions from A1 showing the extensive migration of graft-derived cells into the dentate hilus (A2), the CA1 subfield (A3), and the CA3 subfield (A4) are shown. (B1 and B2) Another example of robust migration of cells into the DH from an hMGE graft core located in the hippocampal fissure and the adjoining CA1 and CA3 subfields. DH, dentate hilus; ML, molecular layer; SGZ, subgranular zone; SO, stratum oriens; SP, stratum pyramidale; SR, stratus radiatum. (Scale bars: A1, 400 μm; B1, 200 μm; A2–A4 and B2, 100 μm.)