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. 2019 Jan 4;11:1. doi: 10.1186/s13073-018-0611-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Detection of SNVs in NA12878 cfDNA dilution series. a Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from 50 ng input DNA (left) and zoom-in for expected VAF < 5% (right). b Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from 10 ng input DNA (left) and zoom-in for expected VAF < 5% (right). c Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from 5 ng input DNA (left) and zoom-in for expected VAF < 5% (right). d Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from post-NGS library input DNA (left) and zoom-in for expected VAF < 5% (right)