Table 2.
Changes in haemodynamics and blood gases from baseline to end-surgery in the two groups of patients receiving balanced anaesthesia or total intravenous anaesthesia
| Balanced anaesthesia | TIVA | p for interaction (2-way ANOVA) | |||
|---|---|---|---|---|---|
| baseline | end-surgery | baseline | end-surgery | ||
| MAP (mmHg) | 94 ± 18 | 86 ± 13* | 92 ± 14 | 81 ± 12** | 0.642 |
| HR (bpm) | 67 ± 13 | 71 ± 11 | 70 ± 13 | 71 ± 14 | 0.521 |
| CI (ml/m2/min) | 2.4 ± 0.7 | 3.2 ± 0.6*** | 2.6 ± 0.5 | 2.8 ± 0.7 | 0.005 |
| SVRI (dyn*s*cm− 5) | 2800 [2352–3224] | 1839 [1691–2085]*** | 2488 [2203–2952] | 2119 [1754–2350]*** | – |
| pH | 7.42 [7.39–7.47] | 7.40 [7.38–7.43] | 7.43 [7.42–7.44] | 7.41 [7.37–7.45] | – |
| PaO2 (mmHg) | 70 [62–88] | 159 [145–207]** | 72 [63–166] | 194 [134–235]*** | – |
| PaCO2 (mmHg) | 38 ± 4 | 38 ± 4 | 37 ± 3 | 39 ± 5* | 0.027 |
| Base excess (mEq/l) | 0.5 [−0.3, + 2.5] | − 0.4 [− 3.2, + 1.2]** | 0.5 [− 1.4, + 1.2] | − 0.4 [− 1.9, + 2.4] | – |
| ScvO2 (%) | 72 [69–78] | 90 [82–92]*** | 79 [70–90]# | 91 [86–94]** | – |
| Lactate (mmol/l) | 0.6 [0.6–0.8] | 1.3 [1.1–1.9]*** | 0.7 [0.6–1.0] | 1.3 [1.0–1.5]*** | – |
| Hb (g/dl) | 13.3 ± 2.0 | 11.8 ± 0.8*** | 13.4 ± 1.6 | 11.8 ± 1.3*** | 0.793 |
| Glucose (mg/dl) | 96 [86–107] | 121 [105–131]*** | 102 [95–112] | 125 [106–141]*** | – |
*p < 0.05 **p < 0.01 ***p < 0.001 versus baseline, #p < 0.05 versus time-matched balanced anaesthesia. Two-way Analysis of Variance (ANOVA) with Sidack’s multiple comparisons test or Wilcoxon and Mann-Whitney U test, as appropriate. Data are expressed as mean ± standard deviation or median [1st-3rd quartile], as appropriate. TIVA total intravenous anaesthesia, MAP mean arterial pressure, HR heart rate, CI cardiac index, SVRI systemic vascular resistance index, PaO2 arterial oxygen tension, PaCO2 arterial carbon dioxide tension, ScvO2 central venous oxygen saturation, Hb haemoglobin