Table 2.
Peroxiomal Genes Identified in Nephromyces and Cardiosporidium and Their Functional Category
| Protein | Abbr. | Vb | Cv | C | N | Tg | Pf | Cp | |
|---|---|---|---|---|---|---|---|---|---|
| Glyoxylate pathway | |||||||||
| Isocitrate lyase | ICL | x | x | − | − | − | − | − | |
| MLS | MLS | x | x | x | − | − | − | ||
| Citrate synthase | CS | x | x | x | x | x | x | − | |
| Aconitase | ACO | x | x | x | x | x | x | − | |
| Malate dehydrogenase | MDH | x | x | x | x | x | x | x | |
| Peroxisome | |||||||||
| Biogenesis factor 1 | Pex1 | x | x | − | x | x | − | − | |
| Biogenesis factor 2 | Pex2 | x | x | x | x | x | − | − | |
| Biogenesis factor 3 | Pex3 | x | x | − | − | x | − | − | |
| Ubiquitin carrier protein | Pex4 | x | x | x | x | x | x | x | |
| Biogenesis protein 5 | Pex5 | x | x | x | x | x | − | − | |
| Biogenesis protein 6 | Pex6 | x | x | x | x | x | − | − | |
| Biogenesis protein 7 | Pex7 | x | x | x | x | x | − | − | |
| Biogenesis protein 10 | Pex10 | x | x | x | x | x | − | − | |
| Biogenesis factor 11 | Pex11 | x | x | x | x | x | − | − | |
| Biogenesis protein 12 | Pex12 | x | x | − | x | x | − | − | |
| Biogenesis factor 13 | Pex13 | − | − | − | − | − | − | − | |
| Membrane protein 14 | Pex14 | x | x | x | x | x | − | − | |
| Membrane protein 15 | Pex15 | − | − | − | − | − | − | − | |
| Biogenesis factor 16 | Pex16 | x | x | − | − | x | − | − | |
| Membrane protein receptor | Pex19 | x | − | − | − | − | − | − | |
| Biogenesis protein 22 | Pex22 | x | x | x | x | x | x | x | |
| Biogenesis factor 26 | Pex26 | − | − | − | − | − | − | − | |
| Membrane channel | PMP22 | x | x | x | x | − | − | − | |
| Membrane protein 4 | PMP27 | − | − | − | − | − | − | − | |
| ATP/ADP-transporter | PMP34 | x | x | x | x | x | − | − | |
| Fatty acid ABC-transporter | PMP70 | x | x | x | x | x | − | − | |
| ROS metabolism | MPV17 | x | x | x | x | x | x | − | |
| Protein | Abbr. | Vb | Cv | C | N | Tg | Pf | Cp | |
| Fatty acid oxidation | |||||||||
| α-Oxidation | 2-Hydroxyacyl-CoA lyase | HPCL2 | − | x | − | − | − | x | − |
| Phytanoyl-CoA hydrolase | PHYH | x | x | − | − | − | − | − | |
| β-Oxidation | α-Methylacyl-CoA-racemase | AMACR | − | − | − | − | − | − | − |
| Acyl-CoA-oxidase | ACOX | x | x | x | x | x | − | − | |
| Multifunctional protein | DBP | x | x | x | x | x | − | − | |
| Sterole carrier protein 2 | SCPX | − | x | − | − | x | − | − | |
| Multifunctional protein | PBE | − | − | − | − | − | − | − | |
| Acetyl-CoA acyltransferase 1 | ACAA1 | x | x | x | x | x | − | − | |
| 2,4-dienoyl-CoA reductase | PDCR | x | x | x | x | x | − | − | |
| d(3,5)-d(2,4)-dienoyl-CoA isomerase | ECH | x | x | x | x | x | − | − | |
| ATP-binding cassette, subfamily D | ABCD | x | x | x | x | x | − | − | |
| Long-chain acyl-CoA synthetase | ACSL | x | x | x | x | x | x | − | |
| Solute carrier family 27, member 2 | VLACS | x | x | − | − | x | − | − | |
| Other oxidation | Acyl-CoA thioesterase 8 | PTE | − | − | − | − | − | − | − |
| Nucleoside disphosphate-linked m. | NUDT19 | − | x | − | − | − | − | − | |
| Amino acid metabolism | − | − | |||||||
| Multifunctional protein | AGT | x | x | x | x | x | − | − | |
| d-Amino-acid oxidase | DAO | − | − | − | − | − | − | − | |
| Isocitrate dehydrogenase | IDH | x | x | x | x | x | x | − | |
| N1-acetylpolyamine oxidase | PAOX | x | x | − | − | − | − | − | |
| l-Pipecolate oxidase | PIPOX | x | x | − | − | − | − | − | |
| Hydroxymethylgluatryl-CoA lyase | HMGCL | x | x | x | x | x | − | − | |
| (S)-2-hydroxy-acid oxidase | HAO | x | x | x | x | − | − | − | |
| Antioxidant system | − | − | |||||||
| Hydrogen peroxide metabolism | Catalase | CAT | x | − | x | x | x | − | − |
| Superoxide dismutase | SOD | − | − | x | x | x | x | x | |
| Nitric-oxide synthase, inducible | INOS | − | − | − | − | − | − | − | |
| Peroxiredoxin 1 | PRDX1 | x | x | − | x | x | x | x | |
| Peroxiredoxin 5 | PRDX5 | − | − | − | − | − | − | − | |
| Glutathione metabolism | |||||||||
| Glutathione S-transferase kappa 1 | GSTK1 | x | x | x | x | − | − | − | |
| Protein | Abbr. | Vb | Cv | C | N | Tg | Pf | Cp | |
| Etherphospholipid biosynthesis | |||||||||
| Dihydroxyacetone phosphate acyltr. | DHAPAT | x | x | x | x | x | − | − | |
| Alkyldihydroxyacetone phosphate syn | AGPS | x | x | x | − | − | − | − | |
| Fatty acyl-CoA reductase | FAR | x | x | − | x | x | − | − | |
| Purine metabolism | |||||||||
| Xanthine dehydrogenase | XDH | x | x | x | x | − | − | − | |
| Urate oxidase | UO | x | x | x | x | − | − | − | |
| Retinol metabolism | |||||||||
| Dehydrogenase/reductase SDR family | DHRS4 | x | x | x | x | − | − | − | |
| Sterol precursor biosynthesis | |||||||||
| Mevalonate kinase | MVK | − | − | − | − | − | − | − | |
| Phosphomevalonate kinase | PMVK | − | − | − | − | − | − | − | |
Note.—(x) denotes presence of gene and (−) absence. Vb, Vitrella brassicaformis; Cv, Chromera velia; C, Cardiosporidium; N, Nephromyces; Tg, Toxoplasma gondii; Pf, Plasmodium falciparum; Cp, Cryptosporidium parvum. Table modified based on Ludwig-Klinger et al. (2017).