. Freshly isolated PBMC were stained for human CD14, CD16, and CCR2, or with
isotype matched control antibodies. CCR2 MFI was calculated by subtracting the MFI of the
IgG2b isotype matched control staining on CD14+CD16+ monocytes from
the MFI of CCR2 on CD14+CD16+ monocytes. MRI/1H-MRS
imaging was performed within 1–2 weeks of blood draw. Pearson’s correlation
coefficient was used to determine the coefficient of determination (r2). Each
data point is one individual subject. (a). Inverse correlation of NAA/Cr in
the right caudate nucleus with CCR2 on CD14+CD16+ monocytes (n = 18,
p = 0.01, r2 = 0.348). (b). Inverse correlation of Glx/Cr in the
left caudate nucleus with CCR2 on CD14+CD16+ monocytes (n = 16, p =
0.01, r2 = 0.356). (c). Inverse correlation of tCho/tCr in the right caudate
nucleus with CCR2 on CD14+CD16+ monocytes (n = 18, p = 0.03,
r2 = 0.259).