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. 2018 Oct 25;10(4):205. doi: 10.3390/pharmaceutics10040205

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Passive targeting of nanoparticles to bone marrow. (A) Scheme showing passive targeting of NPs (green spheres) into bone. NPs pass through the fenestrations in sinusoidal capillaries to localize in bone marrow. NP (B) charge on blood residence time and (C) bone accumulation. Neutral charge NPs showed greater accumulation in tibia than similarly sized anionic and cationic NPs. (D) Neutral charge NPs showed greater localization in tibia with bone metastasis (white arrow) than healthy tibia. Reprinted with permission from Reference [93].