Table 5.
Participation of identified predictors in the development and progression of prostate cancer according to the OncomiRDB database.
| miRNA | miRNA Function | Sum Effect | Direct Targets |
|---|---|---|---|
| miR-16.5p | Reduce cell proliferation | Tumor-suppressive | FGF2 |
| Inhibit tumor growth | FGFR1 | ||
| miR-20a.5p | Increase cell proliferation | Oncogenic | CX43 |
| Increase colony formation | |||
| miR-23b.3p | Inhibit cell proliferation | Tumor-suppressive | |
| Inhibit colony formation | |||
| Inhibit cell migration | |||
| Inhibit cell invasion | SRC | ||
| Induce cell cycle G0/G1 arrest | AKT1 | ||
| Induce apoptosis | |||
| Inhibit epithelial-mesenchymal transition | |||
| miR-26b.5p | Inhibit cell proliferation | Tumor-suppressive | |
| miR-29a.3p | Inhibit cell growth | TRIM68 | |
| Inhibit cell invasion | |||
| miR-29b.3p | Inhibit wound healing | Tumor-suppressive | |
| Inhibit cell invasion | |||
| Inhibit colony formation | |||
| miR-30d.5p | Promote cell proliferation | Oncogenic | SOCS1 |
| Promote cell invasion | |||
| miR-101.3p | Inhibit cell growth | Tumor-suppressive | COX2 |
| Inhibit tumor growth | |||
| miR-106b.5p | Increase cell adhesion | Oncogenic | CASP7 |
| Promote cell growth | |||
| miR-125b.5p | Promote tumor growth, reduce drug sensitivity | Oncogenic | TP53 BBC3BAK1 |
| miR-141.3p | Enhance cell growth | Oncogenic | |
| miR-200a.3p | Inhibit cell invasion | Tumor-suppressive | GNA13 |
| miR-200b.3p | Inhibit cell migration | Tumor-suppressive | |
| Inhibit cell invasion | |||
| Reduce cell adhesion | |||
| Reduce cell detachment | |||
| miR-200c.3p | Increase adhesion | Tumor-suppressive | |
| Reduce cell invasion | |||
| Reduce cell migration | |||
| miR-205.5p | Increase adhesion | Tumor-suppressive | ZEB1 |
| Reduce cell invasion | |||
| Reduce cell migration | |||
| Inhibit epithelial-mesenchymal transition | VIM | ||
| Inhibit cell migration | |||
| miR-31.5p | Inhibit cell proliferation | Tumor-suppressive | |
| Inhibit cell invasion | |||
| Inhibit cell migration | |||
| miR-99b.5p | Tumor-suppressive | SMARCA5 | |
| Inhibit cell growth | SMARCD1 | ||
| MTOR | |||
| miR-100.5p | Tumor-suppressive | SMARCA5 | |
| Inhibit cell growth | SMARCD1 | ||
| MTOR | |||
| miR-331.3p | Inhibit cell proliferation | Tumor-suppressive | DOHH |