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. 2018 Dec 10;19(12):3967. doi: 10.3390/ijms19123967

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Febuxostat ameliorates kidney fibrosis (A) AZAN staining of kidney fractions, scale bar = 100 μm (left panel), 50 μm (right panel); (B,C) Immunostaining of renal sections with anti-FN or Col4 antibody. Representative images are shown, scale bar = 100 μm (left panel), 50 μm (right panel); (D) Relative mRNA levels of fibrotic markers in the kidneys were measured. (BALB/c control mice: n = 8, untreated gddY mice: n = 4, febuxostat treated gddY mice: n = 8) *: p < 0.05, **: p < 0.01, ***: p < 0.001.