Figure 2.

Course of CMV-specific cell numbers in 13 kidney transplant recipients. Patients were grouped into those with a decrease (n = 4, marked green), an increase (n = 4, red) or constantly undetectable viral load (n = 5, blue). Cells were either stimulated by CMV phosphoprotein 65 (pp65) or CMV immediate early antigen 1 (IE-1) and the secretion of IFN-γ (a,b) or IL-21 (c,d) was analyzed. The frequency is given as delta value of spot forming cells (Δ SFC) per 10⁵ lymphocytes, indicating that negative (autologous) controls were subtracted. ELISpot responses were determined at up to three consecutive time points (1, 2, and 3). An individual icon was assigned to each patient. Mean values at time point 1 and 2 are indicated as numbers and horizontal lines. Δ SFC below 0 were set as 0.