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. 2018 Dec 11;10(4):268. doi: 10.3390/pharmaceutics10040268

Figure 5.

Figure 5

Examples of DNA nanostructures developed for the delivery of small molecules. (a) Anti-neoplastic DOX-loaded DNA triangles and nanotubes for circumvent multidrug resistance, adapted with permission from [162]. (b) Targeted antitumor treatment by the DOX loaded to chemically modified L-TDNs (DOX@L-Tds), adapted with permission from [165]. (c) In vivo evaluation of antitumor effect using F-buckyballs with floxuridine (F), adapted with permission from [170]. (d) Evaluation of the apoptotic effect promoted by DNA TDN and DNA origami integrating 5-fluoro-2’-deoxyuridine (FdU) oligomers and cholesterol moieties, adapted with permission from [171]. (e) Self-degradable DNA nanoclew sensitive to pH changes for the delivery of DOX, adapted with permission from [179]. (f) DNA octahedron with precise delivery of cargo upon photoirradiation in C. elegans, adapted with permission from [114].