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. 2018 Dec 11;10(4):268. doi: 10.3390/pharmaceutics10040268

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Examples of DNA nanostructures for chemotherapy combined with phototherapy. (a) “Sense and Treat” DNA nanodevices incorporating DOX and photosensitizers, depicted as green dots, for synergetic removal of circulating cancer cells. Adapted with permission from [224]. (b) Schematic illustration of the strategy followed by Ding and coworkers, [228] using a triangle DNA origami (MODA) rationally modified with MUC-1 aptamer strands (green), capture strands (blue), gold nanorods (NR), and DOX added through intercalation with DNA base pairs. Adapted with permission from [228]. (c) Schematic representation of Au-GI nanomachine providing triple combination of photothermal, photodynamic and chemotherapy, adapted with permission from [230].