Figure 2.

Examples of immune organs-on chip. (a) skin-on-chip consisting of three PDMS layers and two porous membranes filled with fluid three different colors or containing HaCaT cells [39], (b) bone marrow-on-chip consisting of 4 microchannels and containing SUP-B15 and bone marrow derived stem cell co-culture [40], (c) gut-on-chip consisting of two hollow microchannels separated by a porous membrane containing villus epithelium [41] and (d) lymphatic vessel-on-chip with a specific microchannel pattern containing blood vascular endothelial cells and lymphatic endothelial cells [42].