Figure 3.
Effects of P1R and P2R antagonists on EDR in mesenteric arteries from WT and GK rats. Concentration-response curves for acetylcholine (ACh) in mesenteric arteries preconstricted with PE in the absence and presence of the non-selective P1R antagonist (8PT, 10−5 M) from WT (A, n = 3) or GK (B, n = 4). Concentration-response curves for ACh in mesenteric arteries preconstricted with PE in the absence and presence of the non-selective P2R antagonist (PPADS, 10−5 M) from WT (C, n = 3) or GK (D, n = 4). Data are presented as mean ± SEM as percentage relaxation of PE. No significant differences were detected with two-way ANOVA.