Figure 4.
Effects of specific antagonism for A1R, P2X7R, and P2Y6R on EDR in aortas. Concentration–response curves for acetylcholine (ACh) in aortas preconstricted with PE in the absence and presence of the A1R antagonist (DPCPX, 10−8 M) (A, WT n = 3; D, GK n = 7), the P2X7R antagonist (A438079, 10−5 M) (B, WT n = 4; E, GK n = 10), and the P2Y6R antagonist (MRS2578, 10−5 M) (C, WT n = 3; F, GK n = 8). Data are presented as mean ± SEM as percentage relaxation of PE. * p < 0.05 calculated with two-way ANOVA.