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. 2018 Dec 7;19(12):3942. doi: 10.3390/ijms19123942

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Vasoconstrictor response to Up₄A at baseline in arteries from WT and GK rats. Comparison of concentration response curves to cumulative application of Up₄A in aortas (A, WT n = 18, GK n = 32) or mesenteric arteries (B, WT n = 7, GK n = 8) between WT and GK rats. Effects of nitric oxide synthase inhibitor L-NAME on Up₄A-induced contraction in aortas of WT and GK rats (C, WT n = 5; D, GK n = 9). Data are presented as mean ± SEM as percentage contraction of KCl. * p < 0.05; ** p < 0.01; *** p < 0.001, calculated with two-way ANOVA.