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Effects of the P1R and P2R antagonists on vasoconstrictor response to Up4A in aortas from WT and GK rats. Concentration response curves for Up4A in aortas in the absence and presence of the non-selective P1R antagonist (8PT, 10−5 M) (A, WT n = 3; B, GK n = 8) and the non-selective P2R antagonist (PPADS, 10−5 M) (C, WT n = 4; D, GK n = 6). Data are presented as mean ± SEM as percentage contraction of KCl. * p < 0.05, calculated with two-way ANOVA.
