Figure 7.
Effects of specific antagonism for A1R, P2X7R, and P2Y6R on vasoconstrictor response to Up4A in aortas from WT and GK rats. Concentration response curves for Up4A in aortas in the absence and presence of the A1R antagonist (DPCPX, 10−8 M) (A, WT n = 3; D, GK n = 4), the P2X7R antagonist (A438079, 10−5 M) (B, WT n = 6; E, GK n = 6), and the selective P2Y6R antagonist (MRS2578, 10−5 M) (C, WT n = 3; F, GK n = 4). Data are presented as mean ± SEM as percentage contraction of KCl. * p < 0.05 calculated with two-way ANOVA.