Figure 2.

A schematic illustration of connective bridge between the BBB opening (on the example of FITC-dextran) and activation of the lymphatic clearance: I illustrates the BBB opening for FITC-dextran (the red bolls); the green arrows show movement of the extravasated FITC-dextran from the brain tissues into the meningeal lymphatic vessels; II demonstrates movement of FITC-dextran in the cerebral lymphatic network; III show that after the BBB opening, FITC-dextran moves from the meningeal lymphatics (II) into the deep cervical lymph nodes (the red dotted boxes).