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UPLC-MS/MS chromatograms of atractylenolide III (peak 3). (A) Blank plasma, (B) blank plasma spiked with atractylenolide III at the LOQ of 4 ng/mL (spiked with IS), (C) plasma sample 1.5 h after oral administration of raw Atractylodis Rhizoma at a dose of 3.75 g/kg, and (D) plasma sample 1.5 h after oral administration of wheat bran-processed Atractylodis Rhizoma at a dose of 3.75 g/kg.
