Table 5.
Freeze-thaw stability of atractylenolides I, II, and III, and atractyloside A in rat plasma.
| Compounds | Added (ng/mL) | Zero Time Measured C (ng/mL) | One Time Measured C (ng/mL) | Two Time Measured C (ng/mL) | RE (%) |
|---|---|---|---|---|---|
| Atractylenolide I | 5.6 | 5.95 | 5.04 | 5.02 | −4.70 |
| 28 | 28.42 | 28.50 | 28.01 | 1.11 | |
| 140 | 141.30 | 140.01 | 140.22 | 0.36 | |
| Atractylenolide II | 8 | 8.78 | 8.46 | 8.28 | 6.33 |
| 40 | 41.37 | 40.88 | 40.43 | 2.23 | |
| 200 | 201.26 | 200.04 | 200.63 | 0.32 | |
| Atractylenolide III | 8 | 8.78 | 8.52 | 7.89 | 4.96 |
| 40 | 40.10 | 40.48 | 40.63 | 1.01 | |
| 200 | 201.30 | 200.07 | 199.67 | 0.17 | |
| Atractyloside A | 6.88 | 6.39 | 6.38 | 6.02 | −8.96 |
| 17.2 | 17.86 | 17.36 | 17.02 | 1.24 | |
| 172 | 172.73 | 171.48 | 171.65 | −0.03 |