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. 2018 Oct 2;10(4):172. doi: 10.3390/pharmaceutics10040172

Figure 6.

Figure 6

Permeability of the mucosal epithelium probed with LY at 10 mM concentration of PEs. Sections of mucosal explants cultured for 1 h with LY in the absence or presence of 10 mM NaC or DDM, respectively. In addition, the sections were immunolabeled for ApN, or Na+/K+-ATPase, a basolateral cell membrane marker. Both NaC and DDM caused extensive denudation at the tips of the villi (arrows), but epithelial integrity with preservation of cell membrane polarity was maintained along the sides of the villi. However, all enterocytes had taken up LY into the cytosol. Bars: 20 µm.