Figure 1.

tRNA m⁷G46 methyltransferase methylates the N7-atom of guanine at position 46 in tRNA and forms m⁷G46. (A) The secondary structure of tRNA is presented in cloverleaf form. Conserved nucleotides are depicted as follows: adenosine, A; guanosine, G; cytidine, C; uridine, U; purine, R; pyrimidine, Y. tRNA (m⁷G46) methyltransferase transfers a methyl-group to the N7-atom of guanine at position 46 in tRNA and forms 7-methylguanine. (B) The L-shaped structure of tRNA is presented. The m⁷G46 forms a tertiary base pair with the C13-G22 base pair in the L-shaped tRNA structure. In the stick model, only atoms are visible and charge is invisible.