Figure 8.

Differential (A) and integral release curves (B) for blank solution of furosemide with and without HP-$\beta$-CD. Continuous lines represent the imperfect mixing Model III predictions with ${\delta }_d=1$ mm, ${\delta }_m=45$$\mathsf{\mu }$m, $D_0^f=5.78\times {10}^{-10}$ m${}^2$/s, $D_m^f=0.5D_0^f$, $D_0^{f+CD}=1.73\times {10}^{-10}$ m${}^2$/s and $D_m^{f+CD}=0.25D_0^{f+CD}$. (A) Differential release curves $c_p\left(t_i\right)$. (B) Integral release curves. $M_t^s$ dashed curves with points represent the integral release curves as evaluated from experimental data and Equation (20) by assuming a perfectly mixed accepting compartment $V_{res}=7.9$ mL. Continuous lines represent the integral release curves as evaluated from the imperfect mixing Model III. Horizontal dot-dashed line represent the amount of drug $M_0$ initially loaded in the donor compartment.