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Src kinase-dependent phosphorylation on Tyr380 rewires Caspase-8 functionality in cancer cells. Phosphorylation on Tyr380 (P-Y380) impairs the apoptotic function of Caspase-8 and promotes its ability to sustain cell adhesion and migration, neoplastic transformation and to impair anoikis. Arrows indicate induction and T-bar indicates inhibition.
