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Drug loading profiles of mPEG-PLGA-PPA copolymers with different block ratios.
| Polymers | Feed Molar Ratio a | Resultant Molar Ratio b | DLC (%) | DLE (%) |
|---|---|---|---|---|
| mPEG44-PLGA9-PPA7 | 1/0.8 | 1/0.9 | 6.7 | 44.2 |
| mPEG44-PLGA9-PPA9 | 1/1.0 | 1/1.2 | 9.1 | 54.4 |
| mPEG44-PLGA9-PPA14 | 1/1.5 | 1/1.6 | 11.2 | 72.1 |
| mPEG44-PLGA9-PPA18 | 1/2.0 | 1/2.1 | 6.3 | 43.0 |
| mPEG44-PLGA20-PPA18 | 1/0.9 | 1/1.1 | 8.9 | 52.1 |
a Feed molar ratio of BLG-NCA/Phe-NCA. b Resultant molar ratio of PLGA/PPA calculated by 1H NMR.
