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. 2018 Nov 28;19(12):3782. doi: 10.3390/ijms19123782

Figure 1.

Figure 1

In vivo determination of brain-derived neurotrophic factor (BDNF) release from hydrogel. ELISA for BDNF content determination in hydrogel—negative control (− con), hydrogel + BDNFHIGH—positive control (+ con), hydrogel + BDNFHIGH at one day after implantation and distal middle cerebral artery occlusion (dMCAo) + hydrogel + BDNFHIGH at 7 and 22 days after implantation. BDNF is continuously and significantly released from the hydrogel over time with majority of the BDNF being released by 22 days post implantation. − con (hydrogel-only) n = 1; +con (hydrogel + BDNFHIGH) n = 1; hydrogel + BDNFHIGH, 1 day, n = 1; dMCAo + hydrogel + BDNFHIGH, 7 days, n = 3; dMCAo + hydrogel + BDNFHIGH, 22 d, n = 3. Error bars indicate the mean ± SEM; * p < 0.05, **** p < 0.0001.